Pengaruh Ekstrak Buah Anggur Merah (Vitis vinifera L)terhadap Kadar Trigliserida Darah Tikus Putih= (Rattus novergicuss) The influence of Red Grapes Extract (Vitis vinifera L) to the Blood Triglyceride Levels White rats (Rattus novergicuss)

Salmah, Orbayinah and Kurnia, Eka Permana (2011) Pengaruh Ekstrak Buah Anggur Merah (Vitis vinifera L)terhadap Kadar Trigliserida Darah Tikus Putih= (Rattus novergicuss) The influence of Red Grapes Extract (Vitis vinifera L) to the Blood Triglyceride Levels White rats (Rattus novergicuss). Artikel Penelitian Kesehatan, 11 (3). pp. 175-180. ISSN -

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Abstract

Buah anggur memiliki kandungan proanthosianidin dan resveratrol yang berkaitan erat dengan pencegahan hiperlipidemia khususnya hipertrigliserida. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah anggur merah (Vitis viniferra L.) terhadap kadar trigliserida darah tikus putih (Rattus norvegicus). Ekstrak anggur merah dibuat dalam berbagai dosis. Dosis I (100mg/200g BB/hari), dosis II(250mg/200g BB/2ml), dan dosis III (500mg/200g BB/hari). Pemberian ekstrak anggur merah dilakukan selama 10 hari. Hasil yang diperoleh menunjukkan bahwa terdapat perbedaan kadar trigliserida yang signifikan sebelum dan sesudah perlakuan pada masing masing kelompok nilai (p<0,05). Pada uji statistik menggunakan one way Anova menunjukkan nilai p=0,000 (p<0,05). Dosis Uji I mengalami penurunan sebesar 32,80 ± 7,99 ml/dL, dosis Uji II yaitu 60,74 ± 2,15 ml/dL, Uji III yaitu 69,41±3,87ml/dL sehingga terdapat perbedaan kadar trigliserida darah tikus putih antar kelompok yang signifikan. Disimpulkan bahwa pemberian ekstrak anggur merah berpengaruh terhadap penurunan kadar trigliserida darah tikus putih secara bermakna. Kata kunci: ekstrak buah anggur, Trigliserida, Rattus norvegicus Abstract Grapes contain proanthosianidin and resveratrol are strongly associated with prevention of hyperlipidemia especially hypertriglyceride. This study aims to determine the influence of red grapes extracts (Vitis viniferra L.) to the white rat blood triglyceride levels (Rattus norvegicus). Red grapes extracts is made in various doses. I dose (100mg/200g BW / day), II dose (250mg/200g BW/2ml), and the third dose (500mg/200g BW / day). Red grapes extract given during 10 days. The results show that there are differences in triglyceride levels significant before and after treatment in each group values (p <0.05). On the statistical test using one way ANOVA showed the value of p = 0.000 (p <0,05). I test dose decreased by 32.80 ± 7.99 ml / dL, the dose Test II is 60.74 ± 2.15 ml / dL, Test III ie 69.41 ± 3.87 ml / dl so that there are differences in blood triglyceride levels rats significantly between groups. It was concluded that red grapes extract influence on decreased levels of blood triglycerides white rats significantly. Key words: grapes extracts, triglyceride, Rattus norvegicus

Item Type: Article
Subjects: Artikel Dosen
Divisions: Fakultas Kedokteran > Pendidikan Dokter (S1)
Depositing User: Irwan syah
Date Deposited: 22 Oct 2018 03:42
Last Modified: 22 Oct 2018 03:42
URI: http://repository.um-palembang.ac.id/id/eprint/231

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